Dakota Joe is a hired gunman. For that reason he arrives at a border ranch in Mexico hired by the landowner Don Carlos, to eliminate the village doctor, a good man who helps the poor. So Dakota Joe decides not to fulfill his commitment and together with a former outlaw who is now honored, they plan to steal all the money that Don Carlos stores in the safe and to support the revolution of Zapata
Maizie Mackey finished with her term at boarding school in Los Angeles, leaves her sweetheart, Bud Stone, and returns to her father's ranch near Ash Forks, Cal. A few weeks later, Bud, lonesome and downhearted, wires Maizie's father that he is coming on to ask a very important question.
Steve Jameson, a cowboy, is having a lonely meal on the range one day when suddenly he is surprised by a stranger, who rushes covertly out of the bushes and begs him, in an excited manner, for food. The newcomer is a Mexican and his strange demeanor and excited manner suggest to Steve that he is a fugitive.
Idaho, returning to the area he left as a boy, gets in the middle of a range feud. He takes the side of Endicott. On the other side is Hollister who is unaware that Idaho is his long lost son.
Tom Reynolds returns to find he is wanted for murder, his gun having been found at the scene. Tom suspects Munro and stages a fight to get a bullet from Monro's gun which he then sees matches the murder bullet. He gets his brother Steve to confess that he Monro forced him to rob the bank with his gun. But at Tom's trial, the bullets are ignored and when Steve fails to appear, Tom is found guilty.
Convicted killer Jim Holden is rescued from the sheriff by his gang, led by Mason and Riley. He is out to get the Hathaway Stage superintendent George Bannister, who was responsible for his conviction and learns the Bannister, his niece (Kay) and Hal Hathaway, son of the stage line owner, are on a cross-country stage. Johnny, a rancher, and Waco, local stage representative head for the stage to warn the passengers, including entertainer Paradise Flo and coffin salesman Pennypacker. Hal takes the stage into Holdin. Johnny and Waco rescue Hal and Bannister before the gang succeeds in hanging the pair.
Horace Longstreet operates the most brutal drug empires in the south, dealing in peyote, cocoa leaves, laudanum and opium. When he learns a young transporter known as the 'Cat' has been skimming profits, he enlists the aid of a Pinkerton detective, now deep in the bottle and dying of tuberculosis. Against his will, Tyrone Burke must kill or capture the young offender, but the Cat has many lives and leads his pursuer or a 'Wizard of Oz'-type journey through the most dangerous and perverse opium dens, cat-houses and drag queen lairs in the 1880's south. In the end, however, is the Cat actually running for his life or has the hunted now become the hunter? A startling, final confrontation brings two forces of extreme evil face to face, gun to gun, and the result may change the entire direction of the future.