A wild-west trader and his New York wife head out for the California by wagon train. The trader is killed enroute, and his wife finds herself with child. She continues on hoping to find a man and a home.
In 1914, the Mexican revolutionary Pancho Villa invites studios to shoot his actual battles against Porfírio Diaz army to raise funds for financing guns and ammunition. The Mutual Film Corporation, through producer D.W. Griffith, interests for the proposition and sends the filmmaker Frank Thayer to negotiate a contract with Pancho Villa himself.
Having masterminded the hold up of his company office, a mining engineer is barred from the industry. He then sets up shop as an assayer, scheming to acquire a rich silver mine lease from its operators.
Frank Magee teams up with Sandy, his father's ex-partner, and falls in love with June Rance, daughter of his father's murderer. Sánchez and Black Pete learn from Sandy the whereabouts of his mine, kill Rance, and attempt to file a claim on the mine. When Frank tries to overtake them, he is too late but finds that June has filed ahead of the Mexicans.
A mysterious epidemic has struck an Old West frontier town and young girls are falling deathly ill. Doc Carter, his lovely daughter Dolores, and preacher Dan Young have their hands full caring for the infirm. When one of the patients dies unexpectedly, Dan notices two puncture wounds on her neck. His investigation leads him to the strange gunslinger Drake Robey, who always seems to be slower on the draw than his opponents, but who—despite being outdrawn, and even shot—always manages to survive these deadly encounters. Dan soon discovers that Drake also has an aversion to crucifixes, sleeps in coffins, and cannot tolerate sunlight...
Manning breaks out of prison and joins Blake's gang of outlaws. Later a paroled Muggs arrives to rejoin the gang. Muggs is the only one who knows where the stolen money is hidden and Manning is after it.
Mike Sturges and his younger brother, Roy, are sentenced to Yuma Penitentiary on a trumped-up train robbery charge. Both endure cruel treatment before Mike escapes to extract revenge on their enemies.
Rowdy Dyer, the weak but tough-acting son of wealthy rancher Dynamite Dyer, greets the stage in which his sister Clare is arriving by disguising himself as a bandit. He fires a shot that causes the horses to bolt. Cowpuncher Arizona Allen stops the horses but is shot at by passenger Dale Collins, the bank manager. Dynamite hires Arizona, and Clare asks him to look after Rowdy. Arizona saves Rowdy from being fleeced by gambler Buck Zaney, thus incurring Zaney's enmity.
A man has kidnaped an engraver and has him forging Mexican bills. He captures wild horses supposedly to sell for hides but uses them to transport the bills across the border. Police captain Juan Reyes (Richard Avonde) is posing as a bandit to uncover the counterfeiters smuggling fake pesos into Mexico, and is assisted by feisty youngsters Red (Michael Chapin) and Judy (Eilene Janssen), who are trying to protect the wild horses being used by the gang. The kids suspect that rancher Big John Harkins (Roy Barcroft) is the leader of the gang and that he is forcing Mexican artist Espinosa (Julian Rivero) to help him.