Looking to make a splash online with his research videos into the existence of Bigfoot, Jim and his girlfriend Kelly take a camping trip to the small town of Willow Creek, California, and the surrounding mountains where the infamous footage of the supposed sasquatch was filmed.
Esoterica collector Dr Maitland buys an unusual skull from his ordinary source; the artifact is what remains of the Marquis De Sade. Much too soon, Maitland discovers that the skull is turning him into a frenzied killer.
Police lieutenant detective Thomas 'Thom' Randall's steady girl-friend, Dr. Jennifer 'Jen' Allen, is Dr. Aaron Michaels's main assistant on his pharmaceutical firm Bellion's research program to cure the highly contagious, fatal infection Guinin. A convicted murderer, whom Thom arrested, is one of their special drug test subjects, but escapes. The convict and Jen are affected by radioactively altered DNA from an experimental reactor used on mosquitoes which transfer quinine. The convict soon mutates into a mosquito-like monster, which sucks its victims dry. By the time Thom and his junior murder brigade partner Charlie Morrison figure out what happens, Jen starts mutating herself.
As the evil Dr. Saville tortures his latest victim, he weaves together three dark and twisted tales in this horror anthology with a simple warning: be careful what you wish for.
Four girls go to a cabin in the woods, which is inhabited by evil. This cabin then ensnares them in a labyrinth of macabre as they must battle their way out.
When troubled teen Lincoln is subjected to severe bullying, he accidentally conjures the vengeful ghost of Moira Karp. Once a teenage girl pushed to suicide, Moira is now an unstoppable force on a mission of gruesome retribution. But when she goes too far, Lincoln must prevent her from spiraling out of control.
Anna is a young aspiring actress. Living in a small and old apartment in the projects and failing all her castings next to more talented young girls, she dreams of being someone else and living another life. During a movie casting, she steals an expensive purse belonging to one of the contestants. Inside of it, she finds a letter informing its rightful owner that her biological parents have revealed their identities. This is the opportunity for Anna to play a role hopefully rewarded with a cash prize. Unfortunately for Anna, she is going to learn the hard way that it is dangerous to play with someone else's identity.
Aaron Quicksilver is a mysterious storyteller whose listeners invariably end up as the subjects of his gruesome, grisly tales. He tells a new bride stranded on a desert highway a horrifying account of a set of carnivorous toy teeth, then entrains a pickpocket with the spine chilling story of an army of murderous, disembodied hands.
The villainous Dr. Fu Manchu races against a team of Englishmen to find the tomb of Ghengis Khan, because he wants to use the relics to cause an uprising in the East to wipe out the white race.
A community is under siege as three Belmont High School coed students go missing with no trace of their whereabouts. The pressure is on the police to capture the culprits responsible. Scouring the school hallways in search of clues, undercover female detective Maggie Rawdon enters Belmont High as a transfer student in an attempt to solve the hideous disappearance of the students. Maggie makes a few new friends and gets invited to a private rave in the country. Just as the group begins to suspect they've taken a wrong turn, the trap springs, and Maggie finds out firsthand what fate has befallen the missing girls.
A mischievous ghost boy is wandering around the town, trying to find his father. Living alone with loneliness, the ghost boy wants to make friends with people. He enjoys making trouble, and causes chaos throughout the villagers.
The town of Shady Grove holds many dark secrets. Amongst those secrets is the sadistic tale of "Shane", a boy who was tortured and chained to a tree as a youngster. Legend has it that for years he survived in the woods all alone until one day he managed to escape. Now, damaged and broken, he wanders those woods in search of blood, with his trademark chains fused to his wrists. Despite years of tales and urban myths, no proof of his existence has ever been discovered, until five unsuspecting teens reveal the truth on an ill-fated trip.
An innocent man on death row witnesses savage killings at the hands of the prison's sadistic Warden. To survive, he must match the brutality in the prison and confront his own horrifying past.
Devoted wife and mother Amani, whose life begins to unravel when her husband returns home with a second wife and an unseen darkness infiltrates her life.